Title
Comparison of vitellogenin responses in zebrafish and rainbow trout following exposure to environmental estrogensComparison of vitellogenin responses in zebrafish and rainbow trout following exposure to environmental estrogens
Author
Faculty/Department
Faculty of Sciences. Biology
Research group
Behavioural Ecology & Ecophysiology
Department of Biology - other
Publication type
article
Publication
New York,
Subject
Chemistry
Biology
Pharmacology. Therapy
Source (journal)
Ecotoxicology and environmental safety. - New York
Volume/pages
56(2003):2, p. 271-281
ISSN
0147-6513
ISI
000185167900010
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In this comparative study, the suitability of the commonly used in vivo biomarker for estrogenicity, vitellogenin (VTG), upon waterborne exposure to known environmental estrogens is evaluated in both male zebrafish (Danio rerio) and juvenile rainbow trout (Oncorhynchus mykiss). The results from initial experiments in which both species were exposed to 4-tert-octylphenol (OP) or 17alpha-ethynylestradiol under semistatic conditions for 3 weeks demonstrated a difference in species sensitivity for OP exposure. Additional dose-response studies (semistatic, 3 weeks) with 4-nonylphenol (20, 100, and 500 mug/L), bisphenol A (40, 200, and 1000 mug/L), dibutylphthalate (40, 200, and 1000 mug/L DBP), and 17beta-estradiol (20 and 100 ng/L E2) were conducted. All these compounds, except for DBP, were found to be estrogenic to both fish species. The results demonstrated a difference in species sensitivity for NP with the zebrafish being about 5 times less sensitive. For the other compounds tested, no indications for a difference in species sensitivity was found. The results from this study demonstrated that both fish species can be used for the detection of VTG as biomarker for estrogenicity, taken into the potential interspecies differences in sensitivity which might be important for the evaluation of fish population effects. (C) 2003 Elsevier Science (USA). All rights reserved.
E-info
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