| Title |
|
|
|
EORTC Early Clinical Studies Group early phase II trial of S-I in patients with advanced or metastatic colorectal cancer
| |
| Author |
|
|
|
| |
| Abstract |
|
|
|
| Cancer of the colon and rectum is one of the most frequent malignancies both in the US and Europe. Standard palliative therapy is based on 5-fluorouracil/folinic acid combinations, with or without oxaliplatin or irinotecan, given intravenously, Oral medication has the advantage of greater patient convenience and acceptance and potential cost savings. S-1 is a new oral fluorinated pyrimidine derivative. In a nonrandomised phase II study, patients with advanced/metastatc colorectal cancer were treated with S-1 at 40 mg m(-2) b.i.d. for 28 consecutive days, repeated every 5 weeks, but by amendment the dose was reduced to 35 mg m-2 during the study because of a higher than expected number of severe adverse drug reactions. In total 47 patients with colorectal cancer were included. In the 37 evaluable patients there were nine partial responses (24%), 17 stable diseases (46%) and II patients had progressive disease (30%). Diarrhoea occurred frequently and was often severe: in the 40 and 35 mg m(-2) group, respectively, 38 and 35% of the patients experienced grade 3-4 diarrhoea. The other toxicites were limited and manageable. S-1 is active in advanced colorectal cancer, but in order to establish a safer dose the drug should be subject to further investigations. (C) 2003 Cancer Research UK. | | |
| Language |
|
|
|
English
| |
| Source (journal) |
|
|
|
The British journal of cancer. - London | |
| Publication |
|
|
|
London : 2003
| |
| ISSN |
|
|
|
0007-0920
| |
| Volume/pages |
|
|
|
88:5(2003), p. 648-653
| |
| ISI |
|
|
|
000182035300002
| |
| Full text (Publisher's DOI) |
|
|
| | |
| Full text (open access) |
|
|
| | |
|