Stent-based cytochalasin D delivery reduces intimal hyperplasia in a porcine coronary model
Frontiers in coronary artery disease
5th International Congress on Coronary Artery Disease, OCT 19-22, 2003, FLORENCE, ITALY
, p. 679-682
University of Antwerp
This study evaluates the efficacy of 20mg cytochalasin D- (CD, an actin-filament inhibitor) eluting, polymer-coated stents on in-stent neointima formation in a porcine coronary model. In vitro release in Tris buffer at 37degreesC was 22% after 24 hours, which was augmented towards 88% after 3 weeks (n=2). Thirty stents (bare, n=10; polymer-only, n=10; CD, n=10) were randomly deployed in. right or left coronary arteries of 15 pigs. Six weeks later, morphometry showed higher neointimal area related to injury in polymer-only as compared to bare stents (1.55+/-0.11 vs 1.26+/-0.11 mm(2), P>0.05), significantly reduced by CD-coated stents (0.96+/-0.10 mm(2), p<0.01). We conclude that stent-based delivery of 20mug CD via a polymer matrix reduces in-stent intimal hyperplasia.