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Title
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Stent-based cytochalasin D delivery reduces intimal hyperplasia in a porcine coronary model
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Author
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Abstract
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| This study evaluates the efficacy of 20mg cytochalasin D- (CD, an actin-filament inhibitor) eluting, polymer-coated stents on in-stent neointima formation in a porcine coronary model. In vitro release in Tris buffer at 37degreesC was 22% after 24 hours, which was augmented towards 88% after 3 weeks (n=2). Thirty stents (bare, n=10; polymer-only, n=10; CD, n=10) were randomly deployed in. right or left coronary arteries of 15 pigs. Six weeks later, morphometry showed higher neointimal area related to injury in polymer-only as compared to bare stents (1.55+/-0.11 vs 1.26+/-0.11 mm(2), P>0.05), significantly reduced by CD-coated stents (0.96+/-0.10 mm(2), p<0.01). We conclude that stent-based delivery of 20mug CD via a polymer matrix reduces in-stent intimal hyperplasia. |
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Language
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English
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Source (journal)
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Frontiers in coronary artery disease
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Source (book)
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5th International Congress on Coronary Artery Disease, OCT 19-22, 2003, FLORENCE, ITALY
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Publication
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2003
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ISBN
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88-323-3161-6
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Volume/pages
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(2003)
, p. 679-682
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ISI
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000187617500137
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