Publication
Title
Risperidone in the treatment of childhood autistic disorder : an open pilot study
Author
Abstract
Objective: To evaluate the tolerability and efficacy of risperidone in childhood autistic disorder. Methods: A multicenter, open-label, dose-titration study involving seven autistic children (mean age 7.6years) receiving risperidone for 4 weeks. Results: Mean dose was 0.01 mg/kg/day on day 1, 0.019 mg/kg/day on day 7 (range 0.01-0.041 mg/kg/day) and 0.035 mg/kg/day on day 28 (range 0.014-0.064mg/kg/day). Over the 4-week period, the Ritvo-Freeman Real Life Rating Scale total score measuring autistic behavior was significantly decreased (P = 0.019), as was the affectual reactions subscale (P = 0.029). Aberrant Behavior Checklist total score was significantly improved (P < 0.001), as were all subscales except inappropriate speech. Visual Analog Scale for individual target symptoms was significantly decreased (P = 0.001), and Clinical Global Impression severity of illness score was significantly improved (P = 0.006). The incidence of adverse effects was low, and no extrapyramidal symptoms were observed. No significant changes or clinically relevant abnormalities occurred in laboratory tests, vital signs or electrocardiograms. Plasma concentrations of the drug were similar to those in adult patients. Conclusions: These favorable results suggest that larger controlled trials of risperidone should be performed in autistic or mentally retarded patients with behavioral disturbances.
Language
English
Source (journal)
Acta neuropsychiatrica. - Leiderdorp
Publication
Leiderdorp : 2002
ISSN
0924-2708
Volume/pages
14:5(2002), p. 242-249
ISI
000179769100008
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 03.07.2017
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