Title
Isolated hypoxic hepatic perfusion (IHHP) using balloon catheter techniques : from laboratory to the clinic towards a percutaneous procedure Isolated hypoxic hepatic perfusion (IHHP) using balloon catheter techniques : from laboratory to the clinic towards a percutaneous procedure
Author
Publication type
article
Publication
Stuttgart ,
Subject
Human medicine
Source (journal)
Hepato-gastroenterology. - Stuttgart
Volume/pages
47(2000) :33 , p. 776-781
ISSN
0172-6390
ISI
000088000900037
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Background/Aims: The success of ana our extensive experience with TNF alpha-based isolated limb perfusions in patients with unresectable extremity soft tissue sarcomas made us explore the possibilities for a similar approach for the treatment of hepatic metastases. After experience with the classic surgical isolated hepatic perfusion in pigs and in patients, we concluded that the classic surgical approach was associated with serious drawbacks i.e., magnitude of the procedure with morbidity, lack of repeatability of the procedure, complexity and costs. These problems were addressed in a program aimed at developing a repeatable method of isolated perfusion of the liver with minimally invasive techniques. Methodology: We validated the methodology of isolated hypoxic hepatic perfusion using balloon catheter techniques in pigs. Results: The excellent pharmacokinetic profile of the procedure, resulting in very high regional drug concentrations and negligible systemic drug concentrations, allowed us to move on to the clinic and start to study and further develop this method in a phase I-II study using the drug melphalan, in patients with irresectable hepatic metastases. Conclusions: We aim to develop step by step a fully percutaneous approach for isolated hypoxic hepatic perfusion.
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088000900037&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088000900037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088000900037&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle