Publication
Title
Isolated hypoxic hepatic perfusion (IHHP) using balloon catheter techniques : from laboratory to the clinic towards a percutaneous procedure
Author
Abstract
Background/Aims: The success of ana our extensive experience with TNF alpha-based isolated limb perfusions in patients with unresectable extremity soft tissue sarcomas made us explore the possibilities for a similar approach for the treatment of hepatic metastases. After experience with the classic surgical isolated hepatic perfusion in pigs and in patients, we concluded that the classic surgical approach was associated with serious drawbacks i.e., magnitude of the procedure with morbidity, lack of repeatability of the procedure, complexity and costs. These problems were addressed in a program aimed at developing a repeatable method of isolated perfusion of the liver with minimally invasive techniques. Methodology: We validated the methodology of isolated hypoxic hepatic perfusion using balloon catheter techniques in pigs. Results: The excellent pharmacokinetic profile of the procedure, resulting in very high regional drug concentrations and negligible systemic drug concentrations, allowed us to move on to the clinic and start to study and further develop this method in a phase I-II study using the drug melphalan, in patients with irresectable hepatic metastases. Conclusions: We aim to develop step by step a fully percutaneous approach for isolated hypoxic hepatic perfusion.
Language
English
Source (journal)
Hepato-gastroenterology. - Stuttgart
Publication
Stuttgart : 2000
ISSN
0172-6390
Volume/pages
47:33(2000), p. 776-781
ISI
000088000900037
UAntwerpen
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 16.08.2017
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