Title
Coevolutionary relationship between helminth diversity and MHC class II polymorphism in rodents Coevolutionary relationship between helminth diversity and MHC class II polymorphism in rodents
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Basel ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
Journal of evolutionary biology. - Basel
Volume/pages
21(2008) :4 , p. 1144-1150
ISSN
1010-061X
ISI
000256687100021
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Parasite-mediated selection on major histocompatibility complex (MHC) genes has mainly been explored at the intraspecific level, although many molecular studies have revealed trans-species polymorphism. Interspecific patterns of MHC diversity might reveal factors responsible for the long-term evolution of MHC polymorphism. We hypothesize that host taxa harbouring high parasite diversity should exhibit high levels of MHC genetic diversity. We test this assumption using data on rodent species and their helminth parasites compiled from the literature. Controlling for similarity due to common descent, we present evidence indicating that high helminth species richness in rodent species is associated with increased MHC class II polymorphism. Our results are consistent with the idea that parasites sharing a long-term coevolutionary history with their hosts are the agents of selection explaining MHC polymorphism.
E-info
https://repository.uantwerpen.be/docman/iruaauth/267d11/d632874.pdf
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