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Title
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A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia : results of a consensus process by an international working group
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Author
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Abstract
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| A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients with essential thrombocythemia ( ET) is lacking. An international working group (WG) was convened to develop a consensus formulation of clinically significant criteria for defining resistance/intolerance to HU in ET. To this aim, an analytic hierarchy process (AHP), a multiple-attribute decision-making technique, was used. The steps consisted of selecting the candidate criteria for defining resistance/intolerance; identifying the motivations that could influence the preference of the WG for any individual criterion; comparing the candidate criteria in a pair-wise manner; and grading them according their ability to fulfill the motivations. Every step in the model was derived by questionnaires or group discussion. The WG proposed that the definition of resistance/intolerance should require the fulfillment of at least one of the following criteria: platelet count greater than 600 000/mu l after 3 months of at least 2 g/day of HU ( 2.5 g/day in patients with a body weight over 80 kg); platelet count greater than 400 00/mu l and WBC less than 2500/mu l or Hb less than 10 g/dl at any dose of HU; presence of leg ulcers or other unacceptable mucocutaneous manifestations at any dose of HU; HU-related fever. |
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Language
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English
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Source (journal)
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Leukemia. - Baltimore, Md, 1987, currens
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Publication
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Baltimore, Md
:
2007
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ISSN
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0887-6924
[print]
1476-5551
[online]
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DOI
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10.1038/SJ.LEU.2404473
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Volume/pages
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21
:2
(2007)
, p. 277-280
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ISI
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000243729800013
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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