Title
A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia : results of a consensus process by an international working group A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia : results of a consensus process by an international working group
Author
Faculty/Department
University Hospital Antwerp
Publication type
article
Publication
Baltimore, Md ,
Subject
Human medicine
Source (journal)
Leukemia. - Baltimore, Md, 1987, currens
Volume/pages
21(2007) :2 , p. 277-280
ISSN
0887-6924
1476-5551
ISI
000243729800013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients with essential thrombocythemia ( ET) is lacking. An international working group (WG) was convened to develop a consensus formulation of clinically significant criteria for defining resistance/intolerance to HU in ET. To this aim, an analytic hierarchy process (AHP), a multiple-attribute decision-making technique, was used. The steps consisted of selecting the candidate criteria for defining resistance/intolerance; identifying the motivations that could influence the preference of the WG for any individual criterion; comparing the candidate criteria in a pair-wise manner; and grading them according their ability to fulfill the motivations. Every step in the model was derived by questionnaires or group discussion. The WG proposed that the definition of resistance/intolerance should require the fulfillment of at least one of the following criteria: platelet count greater than 600 000/mu l after 3 months of at least 2 g/day of HU ( 2.5 g/day in patients with a body weight over 80 kg); platelet count greater than 400 00/mu l and WBC less than 2500/mu l or Hb less than 10 g/dl at any dose of HU; presence of leg ulcers or other unacceptable mucocutaneous manifestations at any dose of HU; HU-related fever.
E-info
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