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Title
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Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
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Author
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Abstract
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| Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP. (C) 2000 Cancer Research Campaign. |
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Language
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English
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Source (journal)
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The British journal of cancer. - London
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Publication
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London
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2000
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ISSN
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0007-0920
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DOI
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10.1054/BJOC.1999.1032
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Volume/pages
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82
:5
(2000)
, p. 1000-1003
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ISI
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000085696800002
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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