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Title
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Immunomodulatory influence of CD26 dipeptidyl-peptidase IV during acute and accelerated rejection
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Author
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Abstract
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| Background: The intrinsic catalytic dipeptidyl peptidase IV activity of the T cell activation Ag CD26 is crucial for its costimulatory efficacy. Methods:In this study, we investigated the immunomodulatory effect of CD26/DPP IV,by targeting its catalytic moiety. Results: Treated recipients showed a significant and rapid decrease in TCR, CD3 and CD45 cellular expression kinetics on PBL and a reduction in IL-2 and IFN-gamma intragraft mRNA expression. Enzymatic inhibition during sensitization abrogated accelerated rejection in > 50% of treated recipients. Conclusion: These findings further support the hypothesis that DPP IV/CD26 is associated with allo-Ag mediated immune responses, indicating a graded but central involvement in pathways of cellular and humoral immunity. |
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Language
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English
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Source (journal)
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Langenbeck's Archives of Surgery. - Berlin
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Publication
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Berlin
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1999
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ISSN
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1435-2443
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Volume/pages
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S:1
(1999)
, p. 241-245
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ISI
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000079601800049
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