Immunomodulatory influence of CD26 dipeptidyl-peptidase IV during acute and accelerated rejection
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Langenbeck's Archives of Surgery. - Berlin
, p. 241-245
University of Antwerp
Background: The intrinsic catalytic dipeptidyl peptidase IV activity of the T cell activation Ag CD26 is crucial for its costimulatory efficacy. Methods:In this study, we investigated the immunomodulatory effect of CD26/DPP IV,by targeting its catalytic moiety. Results: Treated recipients showed a significant and rapid decrease in TCR, CD3 and CD45 cellular expression kinetics on PBL and a reduction in IL-2 and IFN-gamma intragraft mRNA expression. Enzymatic inhibition during sensitization abrogated accelerated rejection in > 50% of treated recipients. Conclusion: These findings further support the hypothesis that DPP IV/CD26 is associated with allo-Ag mediated immune responses, indicating a graded but central involvement in pathways of cellular and humoral immunity.