Title
Effect of amphetamine on long-term retention of verbal material Effect of amphetamine on long-term retention of verbal material
Author
Faculty/Department
Faculty of Sciences. Mathematics and Computer Science
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Berlin ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Psychopharmacology. - Berlin
Volume/pages
119(1995) :2 , p. 155-162
ISSN
0033-3158
ISI
A1995RB39300005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A series of five experiments was conducted to investigate the temporal aspects of human memory consolidation of symbolic material through the administration of amphetamine. Subjects had to recall or recognise unrelated words from a previously presented list. The first experiments support the conjecture, based on animal studies, that amphetamine enhances longterm memory performance. Subsequently, enhancement is demonstrated with oral administration before learning, as well as with intramuscular injection after learning. It is shown that improved recall cannot be explained solely by general arousal or attentional processes, but must be due to consolidation. By introducing different test delays we show that consolidation of symbolic material can be modulated by amphetamine during the ist hour after learning. In a final experiment we demonstrate that the memory enhancement applies to to recall as well as to recognition. The implications of the present results are discussed in the context of recent research on LTP processes.
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