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Title
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Plasma soluble interleukin-2-receptor in depression : relationships to plasma neopterin and serum IL-2 concentrations and HPA-axis activity
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Author
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Abstract
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| The present study examined the plasma concentration of the soluble interleukin-2-receptor (sIL-2R) in depressed subjects in relation to hypothalamic pituitary adrenal (HPA) axis function and plasma neopterin and serum n-2 concentrations. Plasma sIL-2R concentration was significantly higher in depressed patients (n = 47) than in controls (n = 19). There were no significant correlations between plasma sIL-2R and severity of illness. In the depressed subjects, there was a highly significant relationship between plasma sIL-2R and neopterin concentrations. Depressed patients with pathologically increased plasma neopterin levels had significantly higher plasma sIL-2R values than those with normal serum neopterin. There were no significant relationships between plasma sIL-2R and indices of HPA-axis function in depression. There was no significant effect of dexamethasone administration on sIL-2R levels. Significantly more depressed subjects had measurable serum n-2 levels than normal controls. Our data support the notion that a moderate activation of cell-mediated immunity may play a role in the pathophysiology of depression. |
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Language
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English
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Source (journal)
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European psychiatry : the journal of the Association of European Psychiatrists. - Paris, 1991, currens
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Publication
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Paris
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Elsevier
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1995
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ISSN
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0924-9338
[print]
1778-3585
[online]
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DOI
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10.1016/0924-9338(96)80345-2
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Volume/pages
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10
:8
(1995)
, p. 397-403
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ISI
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A1995TN74300006
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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