Publication
Title
Immunoreactivity for c-fos and c-myc protein with the monoclonal-antibodies 14E10 and 6E10 in malignant mesothelioma and non-neoplastic mesothelium of the pleura
Author
Abstract
We studied immunoreactivity for c-fos protein and c-myc protein in malignant mesothelioma (36 cases) and non-neoplastic pleural mesothelium (45 cases) using the murine monoclonal antibodies 14E10 and 6E10. All malignant mesotheliomas and cases with non-neoplastic mesothelium exhibited not only nuclear but also cytoplasmic immunoreactivity for c-fos and c-myc protein in the majority of mesothelial cells. There was no statistically significant difference between the various mesothelioma subtypes or between neoplastic and non-neoplastic mesothelium for c-fos protein immunoreactivity (p>0.05). There was statistically significant difference between neoplastic and nonneoplastic mesothelium for c-myc protein immunoreactivity (p<0.01). We conclude that immunoreactivity for c-fos and c-myc protein is present in both non-neoplastic and neoplastic mesothelium, but that a higher proportion of neoplastic mesothelial cells are immunoreactive for c-myc protein when compared with non-neoplastic mesothelium.
Language
English
Source (journal)
Histology and histopathology. - Murcia
Publication
Murcia : 1995
ISSN
0213-3911
Volume/pages
10:3(1995), p. 639-643
ISI
A1995RP97900013
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 09.03.2017
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