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Title
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Immunoreactivity for c-fos and c-myc protein with the monoclonal-antibodies 14E10 and 6E10 in malignant mesothelioma and non-neoplastic mesothelium of the pleura
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Author
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Abstract
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| We studied immunoreactivity for c-fos protein and c-myc protein in malignant mesothelioma (36 cases) and non-neoplastic pleural mesothelium (45 cases) using the murine monoclonal antibodies 14E10 and 6E10. All malignant mesotheliomas and cases with non-neoplastic mesothelium exhibited not only nuclear but also cytoplasmic immunoreactivity for c-fos and c-myc protein in the majority of mesothelial cells. There was no statistically significant difference between the various mesothelioma subtypes or between neoplastic and non-neoplastic mesothelium for c-fos protein immunoreactivity (p>0.05). There was statistically significant difference between neoplastic and nonneoplastic mesothelium for c-myc protein immunoreactivity (p<0.01). We conclude that immunoreactivity for c-fos and c-myc protein is present in both non-neoplastic and neoplastic mesothelium, but that a higher proportion of neoplastic mesothelial cells are immunoreactive for c-myc protein when compared with non-neoplastic mesothelium. |
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Language
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English
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Source (journal)
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Histology and histopathology. - Murcia, 1986, currens
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Publication
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Murcia
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1995
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ISSN
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0213-3911
[print]
1699-5848
[online]
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Volume/pages
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10
:3
(1995)
, p. 639-643
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ISI
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A1995RP97900013
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