Title
Immunoreactivity for c-fos and c-myc protein with the monoclonal-antibodies 14E10 and 6E10 in malignant mesothelioma and non-neoplastic mesothelium of the pleura Immunoreactivity for c-fos and c-myc protein with the monoclonal-antibodies 14E10 and 6E10 in malignant mesothelioma and non-neoplastic mesothelium of the pleura
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Murcia ,
Subject
Biology
Human medicine
Source (journal)
Histology and histopathology. - Murcia
Volume/pages
10(1995) :3 , p. 639-643
ISSN
0213-3911
ISI
A1995RP97900013
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
We studied immunoreactivity for c-fos protein and c-myc protein in malignant mesothelioma (36 cases) and non-neoplastic pleural mesothelium (45 cases) using the murine monoclonal antibodies 14E10 and 6E10. All malignant mesotheliomas and cases with non-neoplastic mesothelium exhibited not only nuclear but also cytoplasmic immunoreactivity for c-fos and c-myc protein in the majority of mesothelial cells. There was no statistically significant difference between the various mesothelioma subtypes or between neoplastic and non-neoplastic mesothelium for c-fos protein immunoreactivity (p>0.05). There was statistically significant difference between neoplastic and nonneoplastic mesothelium for c-myc protein immunoreactivity (p<0.01). We conclude that immunoreactivity for c-fos and c-myc protein is present in both non-neoplastic and neoplastic mesothelium, but that a higher proportion of neoplastic mesothelial cells are immunoreactive for c-myc protein when compared with non-neoplastic mesothelium.
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