Title
Copper-(i) catalyzed formation of 3-methoxy-2,5-dimethylthiophene and 3,4-dimethoxy-2,5-dimethylthiophene Copper-(i) catalyzed formation of 3-methoxy-2,5-dimethylthiophene and 3,4-dimethoxy-2,5-dimethylthiophene
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Oxford ,
Subject
Chemistry
Source (journal)
Tetrahedron. - Oxford
Volume/pages
50(1994) :39 , p. 11533-11540
ISSN
0040-4020
ISI
A1994PH43200015
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
3-Methoxy-2,5-dimethylthiophene and 3,4-dimethoxy-2,5-dimethylthiophene have been prepared from 3,4-dibromo-2,5-dimethylthiophene and sodium methoxide using Cu(I)Br as a catalyst. The influence of some cosolvents and reaction temperature is investigated. Best results are obtained by refluxing in DMF at 125 degrees C for 4 hours. The mixture is easily separated by flash chromatography.
E-info
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