Title
Binding of <tex>$\left[^{3}H\right]$</tex> paroxetine to platelets of depressed-patients - seasonal differences and effects of diagnostic classification Binding of <tex>$\left[^{3}H\right]$</tex> paroxetine to platelets of depressed-patients - seasonal differences and effects of diagnostic classification
Author
Faculty/Department
Faculty of Applied Economics
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Journal of affective disorders. - Amsterdam
Volume/pages
32(1994) :1 , p. 27-35
ISSN
0165-0327
ISI
A1994PG58300004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
[H-3]Paroxetine is a more reliable ligand for studying the serotonin (5-HT) transporter complex than [H-3]imipramine. The present study investigates [H-3]paroxetine binding to platelets in 54 depressed in-patients (18 minor, 16 simple major and 20 melancholic depressed patients) and 16 healthy controls. There were no significant differences in maximal number of binding sites between depressed subjects and normal controls. There was no correlation between [H-3]paroxetine binding to platelet membranes and severity of depression. [H-3]Paroxetine binding to platelets was significantly higher in spring than in summer, fall and winter.
E-info
https://repository.uantwerpen.be/docman/iruaauth/3e6e4c/acc4104.pdf
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994PG58300004&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994PG58300004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994PG58300004&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle