Publication
Title
Binding of paroxetine to platelets of depressed-patients - seasonal differences and effects of diagnostic classification
Author
Abstract
[H-3]Paroxetine is a more reliable ligand for studying the serotonin (5-HT) transporter complex than [H-3]imipramine. The present study investigates [H-3]paroxetine binding to platelets in 54 depressed in-patients (18 minor, 16 simple major and 20 melancholic depressed patients) and 16 healthy controls. There were no significant differences in maximal number of binding sites between depressed subjects and normal controls. There was no correlation between [H-3]paroxetine binding to platelet membranes and severity of depression. [H-3]Paroxetine binding to platelets was significantly higher in spring than in summer, fall and winter.
Language
English
Source (journal)
Journal of affective disorders. - Amsterdam
Publication
Amsterdam : 1994
ISSN
0165-0327
Volume/pages
32:1(1994), p. 27-35
ISI
A1994PG58300004
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 25.07.2017
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