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Title
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An ab initio 4-21G gradient study of clavulanic acid
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Author
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Abstract
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| The structure of five conformations of the beta-lactamase inhibitor clavulanic acid have been optimized using ab initio gradient methods at the 4-21G level. The conformations of lowest energy possess an intramolecular H bond and also have the lowest pyramidization of N1. Different side-chain conformations lead to (i) differences in anomeric interactions and variations of the hydroxyethylidene geometry and (ii) changes in the geometry of the ring skeleton, which are smaller in the four- than in the five-membered ring. |
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Language
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English
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Source (journal)
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Structural chemistry. - Deerfield Beach, Fla
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Publication
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Deerfield Beach, Fla
:
1992
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ISSN
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1040-0400
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DOI
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10.1007/BF00678556
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Volume/pages
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3
:5
(1992)
, p. 321-327
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ISI
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A1992JY04500003
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Full text (Publisher's DOI)
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