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Title
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Spinal sufentanil in rats : part 2. Effect of adding bupivacaine to epidural sufentanil
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Author
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Abstract
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| Male Wistar rats were injected epidurally with various doses of sufentanil, bupivacaine or sufentanil combined with bupivacaine either 40 or 80-mu-g. Addition of 80-mu-g bupivacaine to sufentanil produced a 2.2- to 3-fold decrease of the lowest ED50 for a tail withdrawal reaction latency > 6 and greater-than-or-equal-to 10 s. The potentiation was already present at low doses. Whereas both 0.16-mu-g sufentanil and 80-mu-g bupivacaine were inactive, the combination of the two drugs resulted in a deep analgesia in all animals. Because the addition of low doses of bupivacaine to sufentanil did not increase the ED50's for side-effects, higher specificity ratios were obtained as compared to sufentanil given alone. These results were discussed with regard to the potentiation of the analgesic properties of epidurally administered lipophylic opioids by local anaesthetics. |
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Language
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English
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Source (journal)
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Acta anaesthesiologica scandinavica. - Copenhagen
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Publication
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Copenhagen
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1992
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ISSN
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0001-5172
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Volume/pages
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36
:3
(1992)
, p. 245-249
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ISI
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A1992HM47800007
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Full text (Publisher's DOI)
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