Title
Quinolone antibacterials : 2. 6-substituted-7-(2-thiazolyl)quinolones and 6-substituted-7-(2-thiazolidinyl)quinolones
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Provo, Utah ,
Subject
Chemistry
Source (journal)
Journal of heterocyclic chemistry. - Provo, Utah
Volume/pages
28(1991) :3 , p. 685-695
ISSN
0022-152X
ISI
A1991HU84300024
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A series of 6-substituted-l-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl- and thiazolidinyl)quinoline-3-carboxylic acids were synthesized. Substitution at the 6-position was H, F or Cl. The Hantzsch method was used for the preparation of the thiazolylquinolones. The thiazolidinylquinolones were synthesized by quaternization of the corresponding thiazolyl analogues, followed by reduction of the obtained thiazolium salts with sodium borohydride in aqueous solution. Antibacterial activity was tested in vitro. The compounds were inactive against Gram-negative bacteria but some of them showed good activity against Gram-positive bacteria and mycobacteria. This activity pattern is rarely found among the quinolone antibacterials.
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