Publication
Title
Quinolone antibacterials : 2. 6-substituted-7-(2-thiazolyl)quinolones and 6-substituted-7-(2-thiazolidinyl)quinolones
Author
Abstract
A series of 6-substituted-l-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl- and thiazolidinyl)quinoline-3-carboxylic acids were synthesized. Substitution at the 6-position was H, F or Cl. The Hantzsch method was used for the preparation of the thiazolylquinolones. The thiazolidinylquinolones were synthesized by quaternization of the corresponding thiazolyl analogues, followed by reduction of the obtained thiazolium salts with sodium borohydride in aqueous solution. Antibacterial activity was tested in vitro. The compounds were inactive against Gram-negative bacteria but some of them showed good activity against Gram-positive bacteria and mycobacteria. This activity pattern is rarely found among the quinolone antibacterials.
Language
English
Source (journal)
Journal of heterocyclic chemistry. - Provo, Utah
Publication
Provo, Utah : 1991
ISSN
0022-152X
Volume/pages
28:3(1991), p. 685-695
ISI
A1991HU84300024
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 10.06.2017
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