Title
Quinolone antibacterials : 1. 7-(2-substituted-4-thiazolyl)quinolones and 7-(2-substituted-4-thiazolidinyl)quinolones Quinolone antibacterials : 1. 7-(2-substituted-4-thiazolyl)quinolones and 7-(2-substituted-4-thiazolidinyl)quinolones
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Provo, Utah ,
Subject
Chemistry
Source (journal)
Journal of heterocyclic chemistry. - Provo, Utah
Volume/pages
28(1991) :3 , p. 673-683
ISSN
0022-152X
ISI
A1991HU84300023
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A series of 7-(2-substituted-4-thiazolyl and thiazolidinyl)-l-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids and their 6-fluoro analogues were synthesized. The Hantzsch method was used for the preparation of the thiazolylquinolones. The thiazolidinylquinolones were synthesized by quaternization of the corresponding thiazolyl analogues, followed by reduction of the obtained thiazolium salts with sodium borohydride in aqueous solution. Antibacterial activity was tested in vitro. Most of the compounds were inactive against Gram-negative bacteria but some of them showed however good activity against Gram-positive bacteria and mycobacteria. This activity pattern is rarely found among the quinolone antibacterials.
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991HU84300023&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991HU84300023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991HU84300023&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle