Title
An indium(III)-catalyzed synthesis of 4,4-dichloro-1-aryl-N-alkyl-1-yn-3-amines via an intermolecular <tex>$C(sp^{2})-C(sp)$</tex> bond formation
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Weinheim ,
Subject
Chemistry
Source (journal)
Advanced synthesis and catalysis. - Weinheim
Volume/pages
354(2012) :18 , p. 3461-3467
ISSN
1615-4150
ISI
000312302900013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
This paper demonstrates an indium(III) triflate-catalyzed reaction of electron-deficient a,a-dichloroaldimines with terminal alkynes leading to a rapid and selective access to highly functionalized propargylic amines in good to excellent yields. The dichloromethylene moiety of the aldimine acts as an activating group to accomplish this transformation under very mild conditions.
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