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Title
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Synthesis of 3-functionalized 3-methylazetidines
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Author
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Abstract
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| 1-t-Butyl- and 1-(4-methylbenzyl)-3-bromo-3-methylazetidines were prepared from the corresponding N-(2,3-dibromo-2-methylpropylidene)alkylamines and their propensity to undergo nucleophilic substitution at the 3-position by different nucleophiles was assessed, providing a convenient access to novel 3-alkoxy-, 3-aryloxy-, 3-hydroxy-, 3-cyano-, 3-carboxy-, 3-(aminomethyl)- and 3-(hydroxymethyl)azetidines. (C) 2011 Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Tetrahedron letters. - Oxford
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Publication
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Oxford
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2012
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ISSN
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0040-4039
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DOI
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10.1016/J.TETLET.2011.10.097
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Volume/pages
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53
:2
(2012)
, p. 107-110
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ISI
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000299582200001
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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