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Title
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Monofluorinated aziridines in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines
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Author
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Abstract
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| Nonracemic C-fluoroaziridines were synthesized for the first time by reaction of fluorocarbene with N-diphenylmethylidene-substituted natural amino acid esters. The products were shown to be used in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines via one-pot process involving isomerization of 2-fluoroaziridines into alpha-fluoro imines and subsequent reaction with alkynyldifluoroborane generated in situ. |
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Language
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English
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Source (journal)
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Russian journal of organic chemistry. - New York
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Publication
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New York
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2010
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ISSN
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1070-4280
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DOI
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10.1134/S1070428010070043
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Volume/pages
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46
:7
(2010)
, p. 976-986
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ISI
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000280923200004
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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