Title
Monofluorinated aziridines in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines Monofluorinated aziridines in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
New York ,
Subject
Chemistry
Source (journal)
Russian journal of organic chemistry. - New York
Volume/pages
46(2010) :7 , p. 976-986
ISSN
1070-4280
ISI
000280923200004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Nonracemic C-fluoroaziridines were synthesized for the first time by reaction of fluorocarbene with N-diphenylmethylidene-substituted natural amino acid esters. The products were shown to be used in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines via one-pot process involving isomerization of 2-fluoroaziridines into alpha-fluoro imines and subsequent reaction with alkynyldifluoroborane generated in situ.
E-info
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