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Monofluorinated aziridines in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines
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| Abstract |
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| Nonracemic C-fluoroaziridines were synthesized for the first time by reaction of fluorocarbene with N-diphenylmethylidene-substituted natural amino acid esters. The products were shown to be used in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines via one-pot process involving isomerization of 2-fluoroaziridines into alpha-fluoro imines and subsequent reaction with alkynyldifluoroborane generated in situ. | |
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| Language |
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English
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| Source (journal) |
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Russian journal of organic chemistry. - New York |
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| Publication |
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New York : 2010
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| ISSN |
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1070-4280
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| Volume/pages |
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46:7(2010), p. 976-986
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| ISI |
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000280923200004
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| Full text (publisher's version - intranet only) |
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