Title
Fluoroaziridines as novel substrates in the modified Petasis reaction: synthesis of monofluorinated propargyl aminesFluoroaziridines as novel substrates in the modified Petasis reaction: synthesis of monofluorinated propargyl amines
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Oxford,
Subject
Chemistry
Source (journal)
Tetrahedron. - Oxford
Volume/pages
64(2008):1, p. 117-123
ISSN
0040-4020
ISI
000254901800012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Reaction of 2-fluoroaziridines with potassium alkynyltrifluoroborates in the presence of BF(3) center dot OEt(2) leads to fluorinated propargyl amines in moderate to good yields. The reaction proceeds as an in situ isomerization of 2-fluoroaziridines to alpha-fluorinated imines, followed by the reaction of the imine with alkynyldifluoroborane, which is generated in situ from the potassium alkynyltrifluoroborates and BF(3)center dot OEt(2). (c) 2007 Elsevier Ltd. All rights reserved.
E-info
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