Publication
Title
Fluoroaziridines as novel substrates in the modified Petasis reaction: synthesis of monofluorinated propargyl amines
Author
Abstract
Reaction of 2-fluoroaziridines with potassium alkynyltrifluoroborates in the presence of BF(3) center dot OEt(2) leads to fluorinated propargyl amines in moderate to good yields. The reaction proceeds as an in situ isomerization of 2-fluoroaziridines to alpha-fluorinated imines, followed by the reaction of the imine with alkynyldifluoroborane, which is generated in situ from the potassium alkynyltrifluoroborates and BF(3)center dot OEt(2). (c) 2007 Elsevier Ltd. All rights reserved.
Language
English
Source (journal)
Tetrahedron. - Oxford
Publication
Oxford : 2008
ISSN
0040-4020
Volume/pages
64:1(2008), p. 117-123
ISI
000254901800012
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 28.01.2013
Last edited 05.12.2017