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Title
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Fluoroaziridines as novel substrates in the modified Petasis reaction: synthesis of monofluorinated propargyl amines
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Author
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Abstract
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| Reaction of 2-fluoroaziridines with potassium alkynyltrifluoroborates in the presence of BF(3) center dot OEt(2) leads to fluorinated propargyl amines in moderate to good yields. The reaction proceeds as an in situ isomerization of 2-fluoroaziridines to alpha-fluorinated imines, followed by the reaction of the imine with alkynyldifluoroborane, which is generated in situ from the potassium alkynyltrifluoroborates and BF(3)center dot OEt(2). (c) 2007 Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Tetrahedron. - Oxford, 1957, currens
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Publication
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Oxford
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2008
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ISSN
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0040-4020
[print]
1464-5416
[online]
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DOI
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10.1016/J.TET.2007.10.067
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Volume/pages
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64
:1
(2008)
, p. 117-123
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ISI
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000254901800012
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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