Title
A simple route to side-chain fluorinated <tex>$\beta$</tex>-lactams from ring-fluorinated aziridines A simple route to side-chain fluorinated <tex>$\beta$</tex>-lactams from ring-fluorinated aziridines
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Lausanne ,
Subject
Chemistry
Source (journal)
Journal of fluorine chemistry. - Lausanne
Volume/pages
128(2007) :2 , p. 114-119
ISSN
0022-1139
ISI
000244329900004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
beta-Lactams bearing a Ph2CF substituent at the C(4)-atorn were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. The transformation was realized using SbF3-mediated isomerization of the monofluoroaziridines to fluorinated aldimines, followed by Staudinger reaction with ketenes. It was shown that this reaction sequence can be performed as a one-pot procedure. (c) 2006 Elsevier B.V. All rights reserved.
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