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Title
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A simple route to side-chain fluorinated -lactams from ring-fluorinated aziridines
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Author
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Abstract
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| beta-Lactams bearing a Ph2CF substituent at the C(4)-atorn were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. The transformation was realized using SbF3-mediated isomerization of the monofluoroaziridines to fluorinated aldimines, followed by Staudinger reaction with ketenes. It was shown that this reaction sequence can be performed as a one-pot procedure. (c) 2006 Elsevier B.V. All rights reserved. |
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Language
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English
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Source (journal)
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Journal of fluorine chemistry. - Lausanne
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Publication
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Lausanne
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2007
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ISSN
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0022-1139
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Volume/pages
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128
:2
(2007)
, p. 114-119
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ISI
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000244329900004
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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