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A simple route to side-chain fluorinated -lactams from ring-fluorinated aziridines
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| Abstract |
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| beta-Lactams bearing a Ph2CF substituent at the C(4)-atorn were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. The transformation was realized using SbF3-mediated isomerization of the monofluoroaziridines to fluorinated aldimines, followed by Staudinger reaction with ketenes. It was shown that this reaction sequence can be performed as a one-pot procedure. (c) 2006 Elsevier B.V. All rights reserved. | |
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English
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| Source (journal) |
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Journal of fluorine chemistry. - Lausanne |
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| Publication |
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Lausanne : 2007
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| ISSN |
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0022-1139
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128:2(2007), p. 114-119
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| ISI |
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000244329900004
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| Full text (publisher's version - intranet only) |
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