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Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines
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| Abstract |
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| 5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved. | |
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English
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| Source (journal) |
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Tetrahedron. - Oxford |
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Oxford : 2001
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0040-4020
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| Volume/pages |
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57:10(2001), p. 2051-2055
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| ISI |
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000167313700024
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| Full text (publishers version - intranet only) |
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