Publication
Title
Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines
Author
Abstract
5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.
Language
English
Source (journal)
Tetrahedron. - Oxford, 1957, currens
Publication
Oxford : 2001
ISSN
0040-4020 [print]
1464-5416 [online]
DOI
10.1016/S0040-4020(01)00024-2
Volume/pages
57 :10 (2001) , p. 2051-2055
ISI
000167313700024
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 28.01.2013
Last edited 26.11.2024
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