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Title
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Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines
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Author
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Abstract
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| 5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Tetrahedron. - Oxford, 1957, currens
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Publication
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Oxford
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2001
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ISSN
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0040-4020
[print]
1464-5416
[online]
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DOI
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10.1016/S0040-4020(01)00024-2
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Volume/pages
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57
:10
(2001)
, p. 2051-2055
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ISI
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000167313700024
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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