Title
Upregulation of chemokines and their receptors in duchenne muscular dystrophy : potential for attenuation of myofiber necrosis Upregulation of chemokines and their receptors in duchenne muscular dystrophy : potential for attenuation of myofiber necrosis
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Source (journal)
Muscle and nerve. - New York, N.Y.
Volume/pages
46(2012) :6 , p. 917-925
ISSN
0148-639X
ISI
000311615100014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Introduction: In Duchenne muscular dystrophy (DMD), the infiltration of skeletal muscle by immune cells aggravates disease, yet the precise mechanisms behind these inflammatory responses remain poorly understood. Chemotactic cytokines, or chemokines, are considered essential recruiters of inflammatory cells to the tissues. Methods: We assayed chemokine and chemokine receptor expression in DMD muscle biopsies (n = 9, average age 7 years) using immunohistochemistry, immunofluorescence, and in situ hybridization. Results: CXCL1, CXCL2, CXCL3, CXCL8, and CXCL11, absent from normal muscle fibers, were induced in DMD myofibers. CXCL11, CXCL12, and the ligandreceptor couple CCL2CCR2 were upregulated on the blood vessel endothelium of DMD patients. CD68+ macrophages expressed high levels of CXCL8, CCL2, and CCL5. Conclusions: Our data suggest a possible beneficial role for CXCR1/2/4 ligands in managing muscle fiber damage control and tissue regeneration. Upregulation of endothelial chemokine receptors and CXCL8, CCL2, and CCL5 expression by cytotoxic macrophages may regulate myofiber necrosis.
E-info
https://repository.uantwerpen.be/docman/iruaauth/c3be65/a6ffbda0432.pdf
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