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Title
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Amyloid pathology influences cerebrospinal fluid levels in dementia with Lewy bodies
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Author
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Abstract
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| A significant proportion of patients with dementia with Lewy bodies (DLB) show Alzheimers disease (AD) pathology like senile plaques and neurofibrillary tangles. Biomarkers in cerebrospinal fluid (CSF), such as amyloid-β1-42 (Aβ1-42), total tau (T-tau), and hyperphosphorylated tau (P-tau181P), are linked to the different pathological hallmarks of AD. We set up a study to investigate the influence of AD co-pathology on CSF biomarker concentrations and profiles in autopsy-confirmed DLB. DLB patients with senile plaques showed significantly lower CSF Aβ1-42 concentrations than DLB patients without senile plaques, but not compared to the AD patients. There were no significant differences in CSF T-tau or P-tau181P concentrations between DLB patients with and without neurofibrillary tangles. A correlation was found between the number of APOE ε4 alleles and Aβ1-42 CSF levels in DLB patients with senile plaques. Although the CSF biomarkers Aβ1-42, T-tau, and P-tau181P have an added diagnostic value for the differential dementia diagnosis, concomitant amyloid pathology in DLB limits the use of CSF Aβ1-42 for the differential diagnosis of AD versus DLB. |
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Language
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English
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Source (journal)
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Journal of Alzheimer's disease. - -
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Publication
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2013
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ISSN
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1387-2877
1875-8908
[Electronic]
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DOI
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10.3233/JAD-122176
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Volume/pages
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35
:1
(2013)
, p. 137-146
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ISI
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000316940000012
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Full text (Publisher's DOI)
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