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Title
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Probiotics enhance the clearance of human papillomavirus-related cervical lesions : a prospective controlled pilot study
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Author
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Abstract
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| Probiotics have been proposed for a number of urogenital infectious conditions. In this study, we examine a possible effect on human papillomavirus (HPV)-related precancerous lesions in cervical cytology. We conducted a prospective controlled pilot study, in which 54 women with an HPV + low-grade squamous intraepithelial lesion diagnosis in their PAP smear were followed for 6 months. The intervention group consumed a daily probiotic drink during the study period; the control group received no treatment, according to common care policy. Outcome measures were the control PAP smear and HPV status after 6 months. Probiotic users had a twice as high chance of clearance of cytological abnormalities (60 vs. 31%, P=0.05). HPV was cleared in 19% of control patients versus 29% of probiotic users (P=0.41). This exploratory pilot study suggests that the probiotic studied promotes the clearance of HPV-related cytological abnormalities. If confirmed, this would represent an entirely new option to manage cervical cancer precursors. European Journal of Cancer Prevention 22:46-51 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. European Journal of Cancer Prevention 2013, 22:46-51 |
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Language
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English
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Source (journal)
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European journal of cancer prevention. - Oxford, 1991, currens
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Publication
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Oxford
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2013
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ISSN
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0959-8278
[print]
1473-5709
[online]
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Volume/pages
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22
:1
(2013)
, p. 46-51
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ISI
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000311901900007
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Full text (Publisher's DOI)
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