Title
Endocrine disruptors and female fertility : focus on (bovine) ovarian follicular physiologyEndocrine disruptors and female fertility : focus on (bovine) ovarian follicular physiology
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Research group
Applied veterinary morphology
Veterinary physiology and biochemistry
Toxicological Centre
Publication type
article
Publication
New york :Elsevier Science,
Subject
Biology
Veterinary medicine
Source (journal)
Theriogenology: an international journal of animal reproduction. - Los Altos, Calif.
Volume/pages
78(2012):9, p. 1887-1900
ISSN
0093-691X
ISI
000310858700002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Throughout the previous century. the production, use and, as a result, presence of chemicals in the environment increased enormously. Consequently, humans and animals are exposed to a wide variety of chemical substances of which some possess the ability to disrupt the endocrine system in the body, thereby denominated as "endocrine disrupting chemicals" (EDCs) or "endocrine disruptors". Because the reproductive system is a target organ for endocrine disruption, EDCs are postulated as one of the possible causes of human subfertility. Within the reproductive system, the ovarian follicle can be considered as an extremely fragile microenvironment where interactions between the oocyte and its surrounding somatic cells are essential to generate a fully competent oocyte. In this review, we explore how EDCs can interfere with the well-balanced conditions in the ovarian follicle. In addition, we highlight the bovine ovarian follicle as an alternative in vitro model for EDC and broader toxicology research. (C) 2012 Elsevier Inc. All rights reserved.
E-info
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