Publication
Title
Endocrine disruptors and female fertility : focus on (bovine) ovarian follicular physiology
Author
Abstract
Throughout the previous century. the production, use and, as a result, presence of chemicals in the environment increased enormously. Consequently, humans and animals are exposed to a wide variety of chemical substances of which some possess the ability to disrupt the endocrine system in the body, thereby denominated as "endocrine disrupting chemicals" (EDCs) or "endocrine disruptors". Because the reproductive system is a target organ for endocrine disruption, EDCs are postulated as one of the possible causes of human subfertility. Within the reproductive system, the ovarian follicle can be considered as an extremely fragile microenvironment where interactions between the oocyte and its surrounding somatic cells are essential to generate a fully competent oocyte. In this review, we explore how EDCs can interfere with the well-balanced conditions in the ovarian follicle. In addition, we highlight the bovine ovarian follicle as an alternative in vitro model for EDC and broader toxicology research. (C) 2012 Elsevier Inc. All rights reserved.
Language
English
Source (journal)
Theriogenology: an international journal of animal reproduction. - Los Altos, Calif.
Publication
New york : Elsevier Science, 2012
ISSN
0093-691X
Volume/pages
78:9(2012), p. 1887-1900
ISI
000310858700002
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.02.2013
Last edited 19.06.2017
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