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Title
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Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents
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Author
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Abstract
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| This letter reports the synthesis and structure-activity relationship (SAR) study of a series of triazine dimers as novel antiviral agents. These compounds were obtained through a bivalent ligand approach in which two triazine moieties are covalently connected by suitable linkers. Several compounds showed submicromolar activity against wild-type HIV-1 and moderate activity against single mutant strains. (C) 2012 Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Bioorganic and medicinal chemistry letters. - Oxford
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Publication
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Oxford
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2012
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ISSN
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0960-894X
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DOI
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10.1016/J.BMCL.2012.09.066
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Volume/pages
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22
:23
(2012)
, p. 7174-7178
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ISI
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000310583100037
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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