Publication
Title
Monogenic and complex forms of obesity : insights from genetics reveal the leptin-melanocortin signaling pathway as a common player
Author
Abstract
The role of genetic factors involved in the etiology of human obesity is beyond question. The identification of the hypothalamic leptin-melanocortin signaling pathway as a critical regulator in energy homeostasis and food intake has been essential for genetic research. In this review, we discuss the involvement of established and novel genes from this pathway in the pathogenesis of obesity. Their roles in monogenic and complex forms of obesity are illustrated by discussing the results of mutation analysis, candidate gene and genome-wide association studies, as well as copy number analysis. While we can conclude from these outcomes that the leptin-melanocortin pathway is of immense importance, there is still a lot of heritability that currently cannot be explained. Future studies implementing genome-wide association studies, genome-wide copy number variant analysis, and whole exome and whole-genome sequencing might aid in finding new variation in the conventional pathways and might reveal new biological pathways implicated in the pathogenesis of obesity.
Language
English
Source (journal)
Critical reviews in eukaryotic gene expression. - Boca Raton, Fla
Publication
Boca Raton, Fla : 2012
ISSN
1045-4403
Volume/pages
22:4(2012), p. 325-343
ISI
000313934200006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 15.02.2013
Last edited 10.06.2017
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