Publication
Title
Neurofilament phosphorylation and their proline-directed kinases in health and disease
Author
Abstract
The intermediate filaments called neurofilaments (NFs) are the main cytoskeleton elements in neurons. They are mainly present in the adult axonal cytoskeleton, where they are extensively phosphorylated and their phosphorylation status is pivotal for their properties and functions. Specific phosphorylation of the C-terminal domains of the large NF subunits has been implicated in radial axonal growth, NF bundling, and NF axonal transport. Many kinases and phosphatases are involved in regulating the NF phosphorylation status, and this complex interplay is of growing interest as hyperphosphorylation of NFs is a hallmark of several neurodegenerative diseases. In this review, we focus on the in vivo relevance of C-tail phosphorylation of the large NF subunits and give an overview of the kinases and phosphatases involved in regulating the phosphorylation status of the NFs.
Language
English
Source (journal)
Journal of the peripheral nervous system. - -
Publication
Oxford , 2012
ISSN
1085-9489
DOI
10.1111/J.1529-8027.2012.00434.X
Volume/pages
17 :4 (2012) , p. 365-376
ISI
000316695800001
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
In vivo modelling of two ulcero-mutilating neuropathies in Drosophila melanogaster
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 16.02.2013
Last edited 02.10.2024
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