Title
Exon-disrupting deletions of **NRXN1** in idiopathic generalized epilepsy Exon-disrupting deletions of **NRXN1** in idiopathic generalized epilepsy
Author
Contributor
Suls, Arvid
Weckhuysen, Sarah
Claes, Lieve
Deprez, Liesbet
Smets, Katrien
Van Dyck, Tine
Deconinck, Tine
De Jonghe, Peter
Jordanova, Albena
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Boston, Mass. ,
Subject
Biology
Human medicine
Source (journal)
Epilepsia. - Boston, Mass.
Volume/pages
54(2013) :2 , p. 256-264
ISSN
0013-9580
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Purpose Neurexins are neuronal adhesion molecules located in the presynaptic terminal, where they interact with postsynaptic neuroligins to form a transsynaptic complex required for efficient neurotransmission in the brain. Recently, deletions and point mutations of the neurexin 1 (NRXN1) gene have been associated with a broad spectrum of neuropsychiatric disorders. This study aimed to investigate if NRXN1 deletions also increase the risk of idiopathic generalized epilepsies (IGEs). Methods We screened for deletions involving the NRXN1 gene in 1,569 patients with IGE and 6,201 controls using high-density oligonucleotide microarrays. Key Findings We identified exon-disrupting deletions of NRXN1 in 5 of 1,569 patients with IGE and 2 of 6,201 control individuals (p = 0.0049; odds ratio (OR) 9.91, 95% confidence interval (CI) 1.9251.12). A complex familial segregation pattern in the IGE families was observed, suggesting that heterozygous NRXN1 deletions are susceptibility variants. Intriguingly, we identified a second large copy number variant in three of five index patients, supporting an involvement of heterogeneous susceptibility alleles in the etiology of IGE. Significance We conclude that exon-disrupting deletions of NRXN1 represent a genetic risk factor in the genetically complex predisposition of common IGE syndromes.
E-info
https://repository.uantwerpen.be/docman/iruaauth/26e086/6454667c35a.pdf
Handle