Title
Quantitative liquid chromatographic analysis of anthracyclines in biological fluids
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Amsterdam ,
Subject
Chemistry
Biology
Source (journal)
Journal of chromatography : B: analytical technologies in the biomedical and life sciences. - Amsterdam, 2002, currens
Volume/pages
879(2011) :25 , p. 2471-2486
ISSN
1570-0232
1873-376X
ISI
000294982600001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Anthracyclines are amongst the most widely used drugs in oncology, being part of the treatment regimen in most patients receiving systemic chemotherapy. This review provides a comprehensive summary of the sample preparation techniques and chromatographic methods that have been developed during the last two decades for the analysis of the 4 most administered anthracyclines, doxorubicin, epirubicin, daunorubicin and idarubicin in plasma, serum, saliva or urine, within the context of clinical and phar-macokinetic studies or for assessing occupational exposure. Following deproteinization, extraction, solid phase extraction or a combination of these techniques, the vast majority of methods utilizes reversed-phase C18 stationary phases for liquid chromatographic separation, followed by fluorescence detection, or, more recently, tandem mass spectrometric detection. Some pros and cons of the different techniques are addressed, in addition to potential pitfalls that may be encountered in the analysis of this class of compounds. (C) 2011 Elsevier B.V. All rights reserved.
E-info
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