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Title
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Five years follow-up following two or three doses of a hepatitis B vaccine in adolescents aged 11-15 years : a randomised controlled study
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Author
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Abstract
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| Background: The standard three-dose schedule of hepatitis B vaccines is frequently not completed, especially in adolescents. A primary study has confirmed the equivalence of a two-dose schedule of an Adult formulation of hepatitis B vaccine [Group HBV_2D] to a three-dose schedule of a Paediatric formulation in adolescents (11-15 years) [Group HBV_3D]. This follow-up study evaluated the five year persistence of antibody response and immune memory against the hepatitis B surface (anti-HBs) antigens five years after completion of primary vaccination. Methods: A total of 234 subjects returned at the Year 5 time point, of which 144 subjects received a challenge dose of hepatitis B vaccine. Blood samples were collected yearly and pre- and post-challenge dose to assess anti-HBs antibody concentrations. Results: At the end of five years, 79.5% (95% confidence interval [CI]: 71.7 - 86.1) and 91.4% (95% CI: 82.3 - 96.8) of subjects who received the two-dose and three-dose schedules, respectively had anti-HBs antibody concentrations >= 10 mIU/mL. Post-challenge dose, all subjects had anti-HBs antibody concentration >= 10 mIU/mL and >94% subjects had anti-HBs antibody concentration >= 100 mIU/mL. All subjects mounted a rapid anamnestic response to the challenge dose. Overall, the challenge dose was well-tolerated. Conclusion: The two-dose schedule of hepatitis B vaccine confers long-term immunogenicity and shows evidence of immune memory for at least five years following vaccination. |
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Language
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English
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Source (journal)
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BMC infectious diseases. - London
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Publication
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London
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2010
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ISSN
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1471-2334
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DOI
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10.1186/1471-2334-10-357
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Volume/pages
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10
(2010)
, 8 p.
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Article Reference
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357
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ISI
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000285919800001
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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