Publication
Title
IgE-mediated allergy to pholcodine and cross-reactivity to neuromuscular blocking agents : lessons from flow cytometry
Author
Abstract
Background: Immunoglubulin E antibody-mediated allergic reactions to opioids are rare and difficult to document correctly. Objective: Assessment of the basophil activation test in the diagnosis of IgE-mediated allergy to the antitussive pholcodine and associated sensitizations to neuromuscular blocking agents (NMBA). Methods: Three patients with a suspected IgE-mediated allergy to pholcodine were investigated using skin tests, quantification of specific IgE, and flow cytometric activation of basophils. Results and conclusion: Flow cytometric activation of basophils, with simultaneous analysis of CD63 appearance and median histamine content per cell, is the only technique capable to correctly document pholcodine allergy. The negative predictive value of basophil activation tests might help to elucidate on the controversial putative cross-reactivity between pholcodine and NMBA.
Language
English
Source (journal)
Cytometry: part B: clinical cytometry. - New York, 2003, currens
Publication
New York : 2013
ISSN
1552-4949
Volume/pages
84:2(2013), p. 65-70
ISI
000315298600002
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 21.02.2013
Last edited 11.06.2017
To cite this reference