Title
IgE-mediated allergy to pholcodine and cross-reactivity to neuromuscular blocking agents : lessons from flow cytometry IgE-mediated allergy to pholcodine and cross-reactivity to neuromuscular blocking agents : lessons from flow cytometry
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York ,
Subject
Human medicine
Source (journal)
Cytometry: part B: clinical cytometry. - New York, 2003, currens
Volume/pages
84(2013) :2 , p. 65-70
ISSN
1552-4949
ISI
000315298600002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Immunoglubulin E antibody-mediated allergic reactions to opioids are rare and difficult to document correctly. Objective: Assessment of the basophil activation test in the diagnosis of IgE-mediated allergy to the antitussive pholcodine and associated sensitizations to neuromuscular blocking agents (NMBA). Methods: Three patients with a suspected IgE-mediated allergy to pholcodine were investigated using skin tests, quantification of specific IgE, and flow cytometric activation of basophils. Results and conclusion: Flow cytometric activation of basophils, with simultaneous analysis of CD63 appearance and median histamine content per cell, is the only technique capable to correctly document pholcodine allergy. The negative predictive value of basophil activation tests might help to elucidate on the controversial putative cross-reactivity between pholcodine and NMBA.
E-info
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