Basphil activation in the diagnosis of life-threatening hypersensitivity reaction to iodinated contrast media : a case reportBasphil activation in the diagnosis of life-threatening hypersensitivity reaction to iodinated contrast media : a case report
Faculty of Medicine and Health Sciences
Translational Pathophysiological Research (TPR)
Acta clinica Belgica. - Leuven, 1946 - 1997
67(2012), 3 p.
University of Antwerp
Hypersensitivity to iodinated radiologic contrast media occurs in 1-3% of patients. A complete allergological work-up requires the identification of the pathogenetic mechanism as well as the identification of safe alternatives. The current diagnostic approach relies upon skin tests, since no other in vitro test is standardized. However skin tests do not have an absolute predictive value, cannot be executed immediately and may expose the patients to the risk of severe reactions. Recently the flow-cytometric evaluation of activated basophils, also known as basophil activation test (BAT), has been introduced. Our case report of a 28-year old female who experiencedan anaphylactic shock immediately after administration of iomeprol supports the role of BAT in the diagnosis and management of hypersensitivity reactions to contrast media. The possibility of shortening the diagnostic work-up without endangering the health of patients represents the main advantage of this test.