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Title
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In vivo effect confirmation of anti-androgenic compounds in sediment contact tests with **Potamopyrgus antipodarum**
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Author
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Abstract
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| In order to investigate the sensitivity of Potamopyrgus antipodarum to anti-androgenic compounds, three spiked sediment tests were performed. The substances benzanthrone (7H-benz[de]anthracen-7-one), traseolide (ATII) and androstenone (5α-Androst-16-en-3-one) were previously identified in an effect-directed analysis study of the river Schijn in the north of Belgium. Although, in previous studies, all of the three compounds exhibited anti-androgenic activities in vitro, only the oxy-PAH benzanthrone had significant stimulating effects on the snails reproduction. The reproduction of P. antipodarum was significantly stimulated, following a sigmoidal dose response curve, whereby an EC50 of 10 ng/g dry sediment was calculated. Mortality was significantly increased at the highest concentration (69 ng/g dry sediment). The results indicate different relative potencies for the in vivo test with P. antipodarum and the in vitro anti-AR-CALUX assay, performed in a previous study. This highlights the importance of combined in vitro and in vivo assays for the effect assessment of field sediments. |
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Language
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English
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Source (journal)
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Journal of environmental science and health : part A: toxic/hazardous substances and environmental engineering. - New York, N.Y., 1998, currens
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Publication
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New York, N.Y.
:
Marcel Dekker
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2013
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ISSN
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1093-4529
[print]
1532-4117
[online]
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DOI
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10.1080/10934529.2013.730387
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Volume/pages
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48
:5
(2013)
, p. 475-480
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ISI
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000314633400001
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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