Title
Continuous infusion of antibiotics in the critically ill : the new holy grail for beta-lactams and vancomycin?Continuous infusion of antibiotics in the critically ill : the new holy grail for beta-lactams and vancomycin?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Laboratory Experimental Medicine and Pediatrics (LEMP)
Faculty of Medicine and Health Sciences - other
Publication type
article
Publication
Berlin/Heidelberg :Springer-Verlag,
Subject
Human medicine
Source (journal)
Annals of intensive care / Société de réanimation de langue française. - Berlin/Heidelberg, 2011, currens
Volume/pages
2(2012), 12 p.
ISSN
2110-5820
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The alarming global rise of antimicrobial resistance combined with the lack of new antimicrobial agents has led to a renewed interest in optimization of our current antibiotics. Continuous infusion (CI) of time-dependent antibiotics has certain theoretical advantages toward efficacy based on pharmacokinetic/pharmacodynamic principles. We reviewed the available clinical studies concerning continuous infusion of beta-lactam antibiotics and vancomycin in critically ill patients. We conclude that CI of beta-lactam antibiotics is not necessarily more advantageous for all patients. Continuous infusion is only likely to have clinical benefits in subpopulations of patients where intermittent infusion is unable to achieve an adequate time above the minimal inhibitory concentration (T > MIC). For example, in patients with infections caused by organisms with elevated MICs, patients with altered pharmacokinetics (such as the critically ill) and possibly also immunocompromised patients. For vancomycin CI can be chosen, not always for better clinical efficacy, but because it is practical, cheaper, associated with less AUC24h (area under the curve >24 h)-variability, and easier to monitor.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/e3e6e3/c7878c7b.pdf
Handle