Publication
Title
Evolution of the **Leishmania braziliensis** species complex from amplified fragment length polymorphisms, and clinical implications
Author
Abstract
In order to get more insight into its evolution and geographical distribution, we investigated the Leishmania (Viannia) braziliensis species complex using amplified fragment length polymorphisms and sequencing of a heat-shock protein 70 gene fragment. Previously, several assays had alluded to the high genetic diversity of the group, and single-locus assays typically identified two species, i.e. L. braziliensis and Leishmania peruviana, with occasional genetic signatures of both in the same strain. By analysis of 53 parasite isolates from Peru, and eight additional ones from other countries, we identified an atypical L. braziliensis cluster, and confirmed the origin of L. peruviana from the L. braziliensis cluster during the colonization of the western Andean coastal valleys. We discuss the clinical and taxonomical implications of our findings in relation to currently used species typing assays. (C) 2012 Elsevier B.V. All rights reserved.
Language
English
Source (journal)
Infection, genetics and evolution. - Amsterdam
Publication
Amsterdam : 2012
ISSN
1567-1348
DOI
10.1016/J.MEEGID.2012.03.028
Volume/pages
12 :8 (2012) , p. 1994-2002
ISI
000312429000051
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 28.02.2013
Last edited 02.10.2024
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