Title
MALDI MS imaging as a tool for biomarker discovery : methodological challenges in a clinical setting MALDI MS imaging as a tool for biomarker discovery : methodological challenges in a clinical setting
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Weinheim :Wiley-VCH ,
Subject
Chemistry
Biology
Source (journal)
Proteomics. Clinical applications. - Weinheim
Volume/pages
6(2012) :11-12 , p. 581-595
ISSN
1862-8346
1862-8346
ISI
000312650700005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
MALDI MS imaging (MSI) is an analytical tool capable of providing spatial distribution and relative abundance of biomolecules directly in tissue. After 15 years of intense efforts to improve the acquisition and quality of molecular images, MSI has matured into an asset of the proteomic toolbox. The power of MSI lies in the ability to differentiate tissue regions that are not histologically distinct but are characterized by different MS profiles. Recently, MSI has been gaining momentum in biomedical research and has found applications in disease diagnosis and prognosis, biomarker discovery, and drug therapy. Although the technology holds great promise, MSI is still faced with a set of methodological challenges presented by the clinical setting. There is a growing awareness regarding this topic and efforts are being taken to develop clear and practical standards to overcome these challenges. This review presents an overview of MALDI MSI as a biomarker discovery tool and recent methodological progress in the field.
E-info
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