Publication
Title
**C. elegans** homologs of insect clock proteins: a tale of many stories
Author
Abstract
As a consequence of the Earth's axial rotation, organisms display daily recurring rhythms in behavior and biochemical properties, such as hormone titers. The neuronal system controlling such changes is best studied in the fruit fly Drosophila melanogaster. In the nematode worm Caenorhabditis elegans, most homologs of these genes function in the heterochronic pathway controlling the (timing of) developmental events. Recent data indicate that in the worm at least one of the genes involved in developmental timing is also active in circadian rhythm control, thereby opening up new perspectives on a central (neuronal) timer interfering with many processes. Also, new neuropeptidergic clock homologs have been identified in nematodes, supporting the idea of a broad range of clock-regulated targets. We will describe the current knowledge on homologous clock genes in C. elegans with a focus on the recently discovered pigment dispersing factor gene homologs. Similarities between developmental and daily timing are discussed.
Language
English
Source (journal)
Annals of the New York Academy of Sciences. - New York, N.Y., 1877, currens
Publication
New York, N.Y. : 2011
ISSN
0077-8923 [print]
1749-6632 [online]
DOI
10.1111/J.1749-6632.2010.05927.X
Volume/pages
1220 (2011) , p. 137-148
ISI
000293198000014
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 11.03.2013
Last edited 22.01.2023
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