Title
Unraveling the protective effect of a **Drosophila** phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
New York ,
Subject
Biology
Human medicine
Source (journal)
Developmental and comparative immunology / International Society of Developmental and Comparative Immunology. - New York
Volume/pages
33(2009) :11 , p. 1186-1195
ISSN
0145-305X
ISI
000269860200006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
This study addresses the biological function of CG18594, a Drosophila melanogaster phosphatidylethanolamine-binding protein (PEBP) that we named PEBP1, by combining fly genetics, survival experiments and differential proteomics. We demonstrate that transgenic flies overexpressing PEBP1 are highly protected against bacterial infection due to the release of immunity-related proteins in their hemolymph. Apart from proteins that have been reported earlier to participate in insect immunity, we also identify proteins involved in metabolism and signaling, and, in addition, twelve (hypothetical) proteins with unknown function. This is the first report demonstrating an immune function for a Drosophila PEBP protein. (C) 2009 Elsevier Ltd. All rights reserved.
E-info
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