Title
Comparison of **Caenorhabditis elegans** NLP peptides with arthropod neuropeptides
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Trends in parasitology. - London
Volume/pages
25(2009) :4 , p. 171-181
ISSN
1471-4922
ISI
000265135900006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Neuropeptides are small messenger molecules that can be found in all metazoans, where they govern a diverse array of physiological processes. Because neuropeptides seem to be conserved among pest species, selected peptides can be considered as attractive targets for drug discovery. Much can be learned from the model system Caenorhabditis elegans because of the availability of a sequenced genome and state-of-the-art postgenomic technologies that enable characterization of endogenous peptides derived from neuropeptide-like protein (NLP) precursors. Here, we provide an overview of the NLP peptide family in C. elegans and discuss their resemblance with arthropod neuropeptides and their relevance for anthelmintic discovery.
E-info
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