Title
Comparative peptidomics of **Caenorhabditis elegans** versus **C. briggsae** by LC-MALDI-TOF MS Comparative peptidomics of **Caenorhabditis elegans** versus **C. briggsae** by LC-MALDI-TOF MS
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Fayetteville, N.Y. ,
Subject
Chemistry
Biology
Pharmacology. Therapy
Source (journal)
Peptides. - Fayetteville, N.Y.
Volume/pages
30(2009) :3 , p. 449-457
ISSN
0196-9781
0196-9781
ISI
000264791300002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Neuropeptides are important signaling molecules that function in cell-cell communication as neurotransmitters or hormones to orchestrate a wide variety of physiological conditions and behaviors. These endogenous peptides can be monitored by high throughput peptidomics technologies from virtually any tissue or organism. The neuropeptide complement of the soil nematode Caenorhabditis elegans has been characterized by on-line two-dimensional liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (2D-nanoLC Q-TOF MS/MS). Here, we use an alternative peptidomics approach combining liquid chromatography (LC) with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry to map the peptide content of C. elegans and another Caenorhabditis species, Caenorhabditis briggsae. This study allows a better annotation of neuropeptide-encoding genes from the C. briggsae genome and provides a promising basis for further evolutionary comparisons. (c) 2008 Elsevier Inc. All rights reserved.
E-info
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