Publication
Title
Comparative peptidomics of **Caenorhabditis elegans** versus **C. briggsae** by LC-MALDI-TOF MS
Author
Abstract
Neuropeptides are important signaling molecules that function in cell-cell communication as neurotransmitters or hormones to orchestrate a wide variety of physiological conditions and behaviors. These endogenous peptides can be monitored by high throughput peptidomics technologies from virtually any tissue or organism. The neuropeptide complement of the soil nematode Caenorhabditis elegans has been characterized by on-line two-dimensional liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (2D-nanoLC Q-TOF MS/MS). Here, we use an alternative peptidomics approach combining liquid chromatography (LC) with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry to map the peptide content of C. elegans and another Caenorhabditis species, Caenorhabditis briggsae. This study allows a better annotation of neuropeptide-encoding genes from the C. briggsae genome and provides a promising basis for further evolutionary comparisons. (c) 2008 Elsevier Inc. All rights reserved.
Language
English
Source (journal)
Peptides. - Fayetteville, N.Y.
Publication
Fayetteville, N.Y. : 2009
ISSN
0196-9781
Volume/pages
30:3(2009), p. 449-457
ISI
000264791300002
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 11.03.2013
Last edited 20.05.2017