Title
Identification of new members of the (short) neuropeptide F family in locusts and **Caenorhabditis elegans** Identification of new members of the (short) neuropeptide F family in locusts and **Caenorhabditis elegans**
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Engineering sciences. Technology
Source (journal)
Annals of the New York Academy of Sciences / New York Academy of Sciences. - New York, N.Y.
Volume/pages
1163(2009) , p. 60-74
ISSN
0077-8923
ISI
000266493400005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Both the long and short neuropeptides F (NPF) represent important families of invertebrate neuropeptides that have been implicated in the regulation of reproduction and feeding behavior. In the present study, two short NPFs (SNRSPS(L)/(I)R(L)/(I)RFamide and SpS(L)/(I)R(L)/(I)RFamide) were de novo sequenced by mass spectrometry in two major pest insects, the desert locust Schistocerca gregaria and the African migratory locust Locusta migratoria. They are two of the most widespread peptides in the locust neuroendocrine system. A peptide that was previously reported to accelerate egg development in S. gregaria is shown to represent a truncated form of long NPF. This peptide is most likely derived by a novel processing mechanism involving cleavage at RY. In addition, an NPF peptide from the nematode Caenorhabditis elegans was isolated and sequenced by tandem mass spectrometry.
E-info
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