Title
Acute vagus nerve stimulation does not suppress spike and wave discharges in "Genetic Absence Epilepsy Rats from Strasbourg" Acute vagus nerve stimulation does not suppress spike and wave discharges in "Genetic Absence Epilepsy Rats from Strasbourg"
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Epilepsy research. - Amsterdam
Volume/pages
59(2004) :2-3 , p. 191-198
ISSN
0920-1211
ISI
000222964000009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
We evaluated the efficacy of vagus nerve stimulation (VNS) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a validated model for absence epilepsy. In the first experiment, we investigated whether VNS applied at seizure onset can interrupt spike and wave discharges (SWD). In the second experiment, we investigated whether SWD are suppressed or shortened in duration when VNS is applied several hours per day. Both control and VNS groups underwent EEG and VNS electrode implantation. For the first experiment, a randomized crossover design was used. Stimuli (amplitude: 3 V; frequency: 30 Hz; pulse duration: 500 mus) were given when an SWD occurred on the EEG. The experiment was repeated the next day. In the second experiment, treated animals were stimulated (amplitude: 1.5 mA; frequency: 30 Hz; pulse duration: 500 mus; on/off time cycle: 30 s/5 min) for 3 h per day, during five consecutive days. In the first experiment, the duration of the SWD was increased on day 1, (P < 0.05). There was no difference in SWD duration on Day 2. In the second experiment, no significant differences could be found in number, duration and EEG frequency of SWD. VNS applied at the onset of an SWD can prolong the duration of SWD in GAERS. As a 5-day stimulation protocol had no effect, long-term VNS might be necessary to affect SWD. (C) 2004 Elsevier B.V. All rights reserved.
E-info
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