Publication
Title
Detection of spike and wave discharges in the cortical EEG of genetic absence epilepsy rats from Strasbourg
Author
Abstract
Genetic absence epilepsy rats from Strasbourg (GAERS) are a strain of Wistar rats in which all animals present spontaneous occurrence of spike and wave discharges (SWD) in the cortical electroencephalogram (EEG). In this paper, we present a method for the detection of SWD, based on the key observation that SWD are quasi-periodic signals. A spectral-comb based analysis method is used to extract the fundamental frequency and the percentage of energy explained by the harmonic spectral components is subsequently used as a detection parameter. It is shown that a maximum sensitivity and specificity of up to 96 per cent can be achieved. We also compared the performance of this method with the methods presented in the literature and conclude that the surplus value of the novel detection method lies in the higher specificity that can be obtained in the analysis of long-term EEG fragments, which are contaminated by artefacts and contain large portions of slow-wave sleep.
Language
English
Source (journal)
Physics in medicine & biology. - London
Publication
London : 2003
ISSN
0031-9155
Volume/pages
48:12(2003), p. 1685-1700
ISI
000184063200002
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 11.03.2013
Last edited 16.09.2017