Title
Detection of spike and wave discharges in the cortical EEG of genetic absence epilepsy rats from Strasbourg Detection of spike and wave discharges in the cortical EEG of genetic absence epilepsy rats from Strasbourg
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Computer. Automation
Source (journal)
Physics in medicine & biology. - London
Volume/pages
48(2003) :12 , p. 1685-1700
ISSN
0031-9155
ISI
000184063200002
Carrier
E
Target language
English (eng)
Abstract
Genetic absence epilepsy rats from Strasbourg (GAERS) are a strain of Wistar rats in which all animals present spontaneous occurrence of spike and wave discharges (SWD) in the cortical electroencephalogram (EEG). In this paper, we present a method for the detection of SWD, based on the key observation that SWD are quasi-periodic signals. A spectral-comb based analysis method is used to extract the fundamental frequency and the percentage of energy explained by the harmonic spectral components is subsequently used as a detection parameter. It is shown that a maximum sensitivity and specificity of up to 96 per cent can be achieved. We also compared the performance of this method with the methods presented in the literature and conclude that the surplus value of the novel detection method lies in the higher specificity that can be obtained in the analysis of long-term EEG fragments, which are contaminated by artefacts and contain large portions of slow-wave sleep.
E-info
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