Publication
Title
Peptidomics in drug research
Author
Abstract
Background: Because of their wide range of functions, endogenous peptides have great potential either as drugs themselves or as drug targets. Objective: To provide an overview of the current use of peptides as drugs (targets) and describe how improvements in peptide biochemistry and the application of peptidomics studies can lead to the discovery of new diagnostic and therapeutic targets. Methods: We discuss the different peptidomics technologies and their application in the study of human and animal disease models, animal venoms, antimicrobial peptides, G-protein-coupled receptor ligands and biomarkers. Results/conclusions: At present, peptide drugs represent a small but growing number of pharmaceutical molecules. The peptidomics methodology, which was introduced 7 years ago to study naturally occurring peptides, will lead to a plethora of new peptide drug leads.
Language
English
Source (journal)
Expert opinion on drug discovery
Publication
2008
Volume/pages
3:4(2008), p. 425-440
ISI
000260175400006
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 14.03.2013
Last edited 20.05.2017