Title
Noise properties of simultaneous dual tracer PET imaging Noise properties of simultaneous dual tracer PET imaging
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
bookPart
Publication
NewYork, N.Y. :IEEE, [*]
Subject
Physics
Human medicine
Engineering sciences. Technology
Computer. Automation
Source (book)
Nuclear Science Symposium/Medical Imaging Conference, October 23-29, 2005, Fajardo, San Juan, Puerto Rico
ISBN
0-7803-9221-3
ISI
000241851904039
Carrier
E
Target language
English (eng)
Abstract
The Cramer-Rao lower bound (CRLB) for one dimensional dual PET imaging of equilibrated tracers was calculated. The CRLB gives us a fundamental limit on the variance one can obtain in simultaneous dual tracer PET imaging when the two tracers are separated based on their difference in tracer half-life. The CRLB depends on the acquisition time, the two tracer half-lives and the ratio of the initial activities of the two tracers. The dual tracer bounds were compared with the bounds found in the single tracer case. Convergence properties of a 2D dual tracer tornographic reconstruction were also investigated. The images were reconstructed using a parametric iterative reconstruction (PIR) algorithm and image quality was compared to the separate mono tracer ML-EM reconstructions. The PIR algorithm was found to recover the two components, however, convergence rates were slower than the mono tracer convergence rates, thus requiring more iterations to reach the same error level. The convergence rate improved drastically for increasing acquisition times. Our analysis can be extended to evaluate the limits of any number of tracer mixtures.
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