Title
Investigation into the genotoxicity of water extracts from hypoxis species and a commercially available hypoxis preparation Investigation into the genotoxicity of water extracts from hypoxis species and a commercially available hypoxis preparation
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
London ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Phytotherapy research. - London
Volume/pages
27(2013) :3 , p. 350-356
ISSN
0951-418X
ISI
000315958400006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We performed an in vitro evaluation of the genotoxic potential of water extracts from four Hypoxis species (Hypoxis hemerocallidea, H. colchicifolia, H. rigidula, H. acuminata) and a commercial preparation thereof using the neutral red uptake (NRU) assay, the alkaline comet assay and the cytome assay in human hepatoma HepG2 cells. The relative cytotoxicity of these samples was established by determining their NI50 values (50% inhibition of NRU), and these results were used for dose-finding in genotoxicity tests. None of the tested extracts were identified as genotoxic in both the alkaline comet assay and cytome assay.
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