Publication
Title
Investigation into the genotoxicity of water extracts from hypoxis species and a commercially available hypoxis preparation
Author
Abstract
We performed an in vitro evaluation of the genotoxic potential of water extracts from four Hypoxis species (Hypoxis hemerocallidea, H. colchicifolia, H. rigidula, H. acuminata) and a commercial preparation thereof using the neutral red uptake (NRU) assay, the alkaline comet assay and the cytome assay in human hepatoma HepG2 cells. The relative cytotoxicity of these samples was established by determining their NI50 values (50% inhibition of NRU), and these results were used for dose-finding in genotoxicity tests. None of the tested extracts were identified as genotoxic in both the alkaline comet assay and cytome assay.
Language
English
Source (journal)
Phytotherapy research. - London
Publication
London : 2013
ISSN
0951-418X
Volume/pages
27:3(2013), p. 350-356
ISI
000315958400006
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 28.03.2013
Last edited 11.07.2017
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